| abstract |
The present invention provides an apolipoprotein structure, an apolipoprotein structure for use as a medicament, a nucleic acid sequence encoding the apolipoprotein structure, a vector comprising the nucleic acid sequence, a method for producing an apolipoprotein structure, and a pharmaceutical composition It relates to the use of the apolipoprotein structure for. The data presented show that the constructs according to the invention can bind to lipids, bind to a strong Apo AI receptor, cublin, are more potent than native Apo AI, and that the constructs of the present invention have a plasma half-life compared to native Apo AI. Document that it has been extended at least three times. Together these data demonstrate that the constructs according to the invention are potent candidates useful for the treatment of cardiovascular disease. n n Apolipoprotein, Myocardial Disease |