| abstract |
The present invention comprises a chemical having the formula (I) or a pharmacologically acceptable salt thereof as an active ingredient, a prophylactic or therapeutic drug for Alzheimer's disease or an amyloid protein fibrosis inhibitor and a prophylactic or therapeutic drug for Alzheimer's disease or an amyloid protein fibrosis inhibitor A nitrogen-containing heteroaryl derivative or pharmacologically acceptable salt thereof having a specific substituent useful as:n n n n n n n n Wherein R 1 , R 2 : H, alkyl; Z 1 , Z 2 : H, alkyl, alkoxy, halogenated alkyl, halogen; Z 3 : alkoxy, SH, alkylthio, NH 2 , mono- or dialkylamino , OH, halogen; Z 4 , Z 5 : H, halogen; A: 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl and the like). |