http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101026267-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-42 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 |
| filingDate | 2008-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101026267-B1 |
| titleOfInvention | How to determine whether a drug is hepatotoxic |
| abstract | The present invention relates to a method for determining the hepatotoxicity of a drug, comprising the step of injecting the drug into a living body, and measuring the concentration of a specific metabolite contained in the urine of the living body. The method of determining the hepatotoxicity of the drug of the present invention (i) after 24 to 48 hours after the test drug administration to the mammals except humans, the urine is collected to determine the metabolites associated with hepatotoxicity contained in urine Measuring the concentration; And (ii) comparing the concentration of the metabolite related to hepatotoxicity contained in the urine with the concentration of the metabolite contained in the urine of the control group not administered the drug, thereby determining whether hepatotoxicity is present. When using the method of determining the hepatotoxicity of the drug of the present invention, unlike the method using the change pattern of the expression level of the conventional gene, there is no need to establish a separate database can save time and cost, and measure Since the concentration of the metabolite is not changed depending on the drug of interest, stable data can be obtained, and thus it can be widely used in the development of new drugs.n n n n Drugs, hepatotoxicity, metabolites, urine |
| priorityDate | 2008-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.