| abstract |
The present invention relates to alkaloid reaction products wherein the alkaloids react with an alkylating agent, preferably thiotepa, after which the unreacted alkylating agent and other water soluble components are washed with water or a suitable water soluble solvent. Removed from the reaction mixture, after which the reaction product can be obtained from the process of precipitation with a strong acid, preferably hydrochloric acid (HCl), to precipitate the water-soluble salts of the reaction products. Precipitated reaction products comprise at least one quaternary alkaloid derivative and are suitable as drugs for prophylactic or therapeutic applications, in particular immune or metabolic disorders, and cancer.n n n n Alkaloids, Kelidin, Celandine |