| abstract |
The present invention relates to a medical device comprising an interventional component for delivering a plurality of beneficial agents and wherein the hydration inhibitor modulates the release of one or more beneficial agents from the device. Hydration inhibitors have a relatively low hydrophilicity compared to beneficial agents (preferably drugs). Suitable beneficial agents of formula I include dexamethasone, estradiol, proliferation inhibitors, platelet inhibitors, anti-inflammatory agents, thrombolytic agents, cytotoxic drugs, cytokine or chemokine binding inhibitors, cell de-differentiation inhibitors, anti-lipemias, matrix metalloaf Rotase inhibitors, cytostatic drugs, or mixtures of these drugs, radiopaque markers, beta-carotene, tocopherols, tocotrienols, and antioxidants.n n n Formula In n n n n n n n Hydration inhibitors, rapamycin, LogP, restenosis, stents. |