http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101008922-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2200-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2200-308 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-483 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-483 |
| filingDate | 2008-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101008922-B1 |
| titleOfInvention | Composition for the prevention or treatment of colorectal cancer, including sculpted thorn extract |
| abstract | The present invention relates to a composition for preventing or treating colorectal cancer, which comprises sculpted thorn extract as an active ingredient. The composition of the present invention comprising a bark thorn extract as an active ingredient exhibits excellent cytotoxicity to colorectal cancer cells, and inhibits the expression and activity of cell cycle regulators Cdc25c, Cdc2 and cyclin B, thereby reducing the cell cycle to G2 / M. It arrests at the stage and inhibits the activity of the transcription factors NF-κB and AP-1 and inhibits the activity of MMP-9 of colorectal cancer cells, effectively inhibiting the metastasis of cancer cells, and also MAPK (Erk, p38MAP kinase and JNK) It stimulates the activity of mitogen-activated protein kinase to induce apoptosis of cancer cells and shows excellent anticancer activity even at the animal individual level. In addition, the composition of the present invention is excellent in safety because it contains a bark thorn extract has been used as a herbal medicine as an active ingredient for a long time.n n n n Colorectal Cancer, Engraver, Thorns, MMP-9 |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20160087486-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012108745-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012108745-A3 |
| priorityDate | 2008-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 127.