http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101004662-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-2264 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate | 2006-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101004662-B1 |
| titleOfInvention | New Peptides Involved in Energy Homeostasis |
| abstract | Expression of mRNA encoding putative 76 amino acids, the secreted protein (“Swirl”), was found to have a negative correlation with fasting triglyceride and cholesterol levels. In order to increase the expression of Swirl mRNA in two mouse obesity models, KK-A y and Lep ob / Lep ob mice, recombinant adenovirus was used. Overexpression of Swirl by adenovirus injection reduced fasting triglyceride and cholesterol levels in two models in a remarkable, reproducible pattern. In addition, a transgenic mouse species overexpressing the Swirl protein was prepared. In addition, expression of major genes involved in lipid formation (fatty acid synthase) and FAS protein levels were reduced by Swirl adenovirus treatment in Lep ob / Lep ob mice. Full length Swirl peptides or derivatives, homologues, analogs or mimetics thereof delivered by oral ingestion, injection, subcutaneous patch or intranasal route may be hypercholesterolemia, hypertriglyceridemia, insulin resistance, obesity, diabetes and / or energy It can be used as a therapeutic or diagnostic agent for imbalance. |
| priorityDate | 2005-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 488.