| abstract |
The present invention relates to antibodies which exhibit an action or antagonistic effect downstream of a receptor which interacts with human DR5 or human DR4 to induce inhibition of cell proliferation and apoptosis. In the present invention, nucleic acids and amino acid sequences of the DR5 and DR4 antibodies were identified, and vectors and cells containing and expressing these sequences were prepared. Methods of using the antibodies of the invention, including treatment of apoptosis-related diseases and treatment of cell growth dysregulation, have also been described in detail. |