| abstract |
The present invention discloses isolated human monoclonal antibodies and antigen binding sites thereof that specifically bind to dendritic cells. Also disclosed are bispecific molecules, immunotoxins and antigen conjugates comprising such antibodies or portions thereof. Human antibodies can be produced in non-human transgenic animals, such as transgenic mice, capable of producing many isotypes of human monoclonal antibodies via V-D-J recombination and isotype conversion. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas producing the human antibodies, and methods of treatment and diagnostics using the antibodies.n n n Dendritic cells, monoclonal antibodies, antigen binding sites. |