| abstract |
Compounds of formula (I ′), N-oxides thereof, pharmaceutically acceptable for the manufacture of a medicament for the prophylaxis or treatment of inflammatory and / or autoimmune diseases mediated through TNF-α and / or IL-12 Uses of salts, quaternary amines and stereochemical isomers:n n n n n n n n Z is halo; C 1-6 alkyl; C 1-6 alkylcarbonyl; Aminocarbonyl; Hydroxy, carboxyl, cyano, amino, amino substituted with piperidinyl, amino, mono- or di (C 1-6 alkyl) amino substituted with C 1-4 alkyl substituted piperidinyl, C 1-6 alkyloxycarbonyl, C 1-6 alkyloxy, piperidinyl, piperazinyl, morpholinyl or thiomorpholinyl a C 1-6 alkyl substituted with; Cyano; Amino; Mono- or di (C 1-6 alkyl) aminocarbonyl; C 1-6 alkyloxycarbonyl; C 1-6 alkylcarbonyloxy; Amino-S (= 0) 2 —; Mono- or di (Ci_ 6 alkyl) amino-S (= 0) 2 ; -C (= NR x ) NR y R z ;n n n Q is optionally substituted C 3-6 cycloalkyl, phenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, benzthiazolyl, benzoxazolyl, benzimidazolyl, indazolyl, or imidazopyridyl ;n n n Q is a radical of the formula:n n n n n n n n L is optionally substituted phenyl or optionally substituted monocyclic 5 or 6-membered partially saturated or aromatic heterocycle or bicyclic partially saturated or aromatic heterocycle;n n n Aryl is optionally substituted phenyl. |