| abstract |
Compounds which bind to α 4 integrins, preferably VLA-4, are disclosed. Some of these compounds also inhibit leukocyte adhesion, in particular leukocyte adhesion mediated by α 4 integrins, preferably VLA-4. Such compounds are useful in the treatment of inflammatory diseases in mammals such as asthma, Alzheimer's disease, atherosclerosis, AIDS, dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, cancer metastasis and myocardial ischemia in mammals, for example. useful. The compounds may also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.n n n Alpha-4 Integrin, VLA-4, White Blood Cells, Attachment, Inflammatory Disease, Rheumatoid Arthritis |