http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100969171-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2820-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10041 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1761 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 |
| filingDate | 2008-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100969171-B1 |
| titleOfInvention | Gene carriers with improved tumor specific expression |
| abstract | The present invention provides a gene expression control sequence comprising: (a) a hypoxia-responsive element (HRE) enhancer sequence; And (ii) a human telomere reverse transcriptase (hTERT) promoter downstream of the HRE sequence; And (b) relates to a gene transporter, particularly recombinant adenoviruses with improved tumor specific expression comprising a gene sequence operatively linked to the gene expression regulatory sequence. The present invention also relates to a pharmaceutical anti-tumor composition comprising the recombinant adenovirus. Recombinant adenovirus of the present invention exhibits an improved effect of selective tumor cell killing ability or high death, and shows a significantly improved anti-tumor effect, especially in hypoacidic conditions. In addition, specific expression of recombinant adenoviruses in cancer cells may increase stability in the body, leading to further improved anti-tumor effects.n n n n Gene Transporter, Adenovirus, HRE, hTERT, TRAIL, Hypoxia, Tumor Cell, Cancer, Gene Therapy |
| priorityDate | 2008-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1094.