| abstract |
The present invention is mediated by a compound of formula (I) and stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof, methods of preparation thereof, pharmaceutical compositions containing the same, and corticosteroid stimulating hormone release factor (CRF) Its use is provided in the treatment of symptoms.n n n <Formula I>n n n n n n n n Wheren n n R is aryl or heteroaryl, each of which is halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halo C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl , May be substituted by 1 to 4 groups selected from halo C 1 -C 6 alkoxy, —C (O) R 5 , nitro, —NR 6 R 7 , cyano and R 8 groups;n n n R 1 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, halo C 1 -C 6 alkyl, halo C 1 -C 6 alkoxy, halogen, NR 6 R 7 Or cyano;n n n R 2 is hydrogen, a C 3 -C 7 cycloalkyl or R 8 group;n n n R 3 is a C 3 -C 7 cycloalkyl or R 9 group; orn n n R 2 and R 3 together with N form a 5 to 14 membered heterocycle which may be substituted by 1 to 3 R 10 groups;n n n R 4 is hydrogen, C 1 -C 6 alkyl, halogen or halo C 1 -C 6 alkyl;n n n R 5 is C 1 -C 4 alkyl, —OR 6 or —NR 6 R 7 ;n n n R 6 is hydrogen or C 1 -C 6 alkyl;n n n R 7 is hydrogen or C 1 -C 6 alkyl;n n n R 8 is a 5-6 membered heterocycle, which heterocycle may be saturated or may have 1 to 3 double bonds, and may be substituted by one or more R 11 groups;n n n R 9 is C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, halo C 1 -C 6 alkoxy, hydroxy, halo, C 1, which may be substituted by one or more groups selected from -C 6 alkyl C 1 -C 6 alkyl;n n n R 10 is an R 8 group, C 3 -C 7 cycloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halo C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 Alkynyl, halo C 1 -C 6 alkoxy, hydroxy, halogen, nitro, cyano, C (O) NR 6 R 7 , phenyl which may be substituted by 1 to 4 R 11 groups;n n n R 11 is C 3 -C 7 cycloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halo C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, halo C 1 -C 6 alkoxy, hydroxy, halogen, nitro, cyano or C (O) NR 6 R 7 ;n n n X is carbon or nitrogen;n n n n is 1 or 2. |