http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100958678-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C62-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F3-02 |
| filingDate | 2008-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100958678-B1 |
| titleOfInvention | Method for preparing cis-dimecrotinic acid and salts thereof |
| abstract | The present invention relates to a method for preparing cis (z) -dimecrotic acid and salts thereof suitable for medical use, the present invention relates to a) 4-methyl-7-hydroxycoumarin and sodium hydroxide of formula (IV) After dissolving in a solvent, dimethyl sulfate was added dropwise to react to prepare 4-methyl-7-methoxycoumarin of the general formula (III); b) adding sodium hydroxide to the 4-methyl-7-methoxycoumarin compound to dissolve it, lowering the temperature to room temperature, and then adding dimethyl sulfate dropwise to react to prepare crude dimethacrylic acid; c) providing a method for preparing dimethamic acid magnesium salt of formula (I) by adding magnesium chloride hydrate to the crude dimecrotinic acid produced in the crude dimecrotinic acid step to separate the intermediate material, It is possible to produce the cis-dimethacyanate magnesium salt in one step without purification, which not only makes the manufacturing process simpler, but also reduces the safety and manufacturing cost of the process by using a safe and relatively inexpensive magnesium chloride hydrate as a salt generating material. Only cis (Z) foams suitable for medicinal use are obtained, thereby enabling the production of high purity pharmaceuticals.n n n Dimecrotic acid, Dimecrotic acid, 3- (2,4-dimethoxy-phenyl) -2-butenoic acid, magnesium chloride hydrate |
| priorityDate | 2008-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.