http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100952200-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-115 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0619 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate | 2007-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100952200-B1 |
| titleOfInvention | Neuroprogenitor cell expansion method and dopamine neuron production method using expanded neuroprogenitor cell population |
| abstract | The present invention relates to neuroprogenitor cell proliferation methods that maintain proliferative capacity and dopamine neuron differentiation potential even after expansion by multiple passages. In addition, the present invention relates to a method for producing dopamine neurons using such expanded neural precursor cells.n n n HES-NP cells expanded several times in vitro in accordance with the present invention have no change in phenotype gene expression and maintain their own ability to differentiate into neurons that exhibit DA neuronal function in vitro. In addition, hES-NP cells can be cryopreserved without losing their differentiation and developmental potential into dopamine neurons. After transplantation into the Parkinson's disease rat model, multiple passaged hES-NP cells survive and differentiate into neurons. The expanded hES-NP cell population according to the present invention can be used for large scale production of experimental and implantable DA neurons.n n n n Embryonic Stem Cells, Neural Progenitor Cells, Passage Culture |
| priorityDate | 2007-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 320.