abstract |
The present invention relates to novel naturally occurring human cytokines composed of heterodimers of interleukin-17 and interleukin-17F, referred to herein as interleukin 17A / F (IL-17A / F). The present invention also provides a vector comprising a nucleic acid sequence and a host cell, a chimeric polypeptide molecule comprising a polypeptide of the invention fused to a heterologous polypeptide sequence, a specific antibody binding to a polypeptide of the invention, and a polypeptide of the invention. It provides a method of manufacturing. The present invention also provides methods of treating degenerative cartilage disorders and other inflammatory diseases.n n n n Cytokines, Interleukin 17A / F, Degenerative Cartilage Disorders, Inflammatory Disease |