abstract |
Novel acyl urea, thiourea, carbamate, thiocarbamate effective in inhibiting cytokine-mediated inflammatory responses in cultured cells, alleviating bone destruction in animal models of arthritis, and lowering blood glucose levels in animal models of type II diabetes And related compounds. These compounds disclosed herein are useful in several therapies including the treatment of diabetes, insulin resistance, inflammation, inflammatory diseases, immune diseases, cancer. |