http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100925070-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate | 2002-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100925070-B1 |
| titleOfInvention | Protein Matrix for Tissue Engineering Modified with Growth Factors |
| abstract | Proteins are introduced into proteins or polysaccharide matrices used in tissue healing, regeneration and / or remodeling and / or drug delivery. The protein is introduced such that the matrix is degraded and released by enzymatic action and / or diffusion. As demonstrated by the examples, there is a method of forming heparin-metrics by binding heparin to the matrix through a shared or non-shared method. The heparin noncovalently binds the heparin-binding growth factor to the protein matrix. Alternatively, a fusion protein can be constructed that contains crosslinking domains such as Factor XIIIa substrates and native protein sequences. The introduction of a degradable bond between the matrix and the bioactive factor may be useful where long-term drug delivery is desired, eg in the case of nerve regeneration, where the release rate of the drug varies spatially depending on the regeneration function, for example. This is especially useful where it is desirable to move faster near the living tissue surface and slower in the wound area. Additional advantages include lower total drug dose in the delivery system, and spatial control of release to enable the release of a greater proportion of the drug at the point of maximum cellular activity.n n n n Fibrin, bone healing, PTH, protein, tissue, growth factor |
| priorityDate | 2001-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 323.