| abstract |
The present invention relates to substituted methylene amide derivatives of formula (I) and diabetes type I and / or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, polycystic ovary syndrome (PCOS) It relates to the use of said derivative for the treatment and / or prevention of metabolic diseases mediated by insulin resistance or hyperglycemia. In particular, the present invention relates to the use of substituted methylene amide derivatives of formula (I) to modulate to inhibit the activity of PTPs. The present invention also relates to a method of treating type II diabetes, obesity and regulating the appetite of a mammal. Moreover, the present invention relates to novel substituted methylene amide derivatives and methods for their preparation.n n n Formula (I)n n n n n n n n n Methyleneamide derivatives, insulin resistance, hyperglycemia, appetite control, obesity |