| abstract |
The present invention provides antibodies having two specificities for two different but structurally related antigens. The antibody can be, for example, a whole human antibody, a recombinant antibody, or a monoclonal antibody. Preferred antibodies have dual specificity for IL-1α and IL-1β and neutralize IL-1α and IL-1β activity in vitro and in vivo. Antibodies of the invention may be full length antibodies or antigen-binding portions thereof. Methods of making and methods of using the antibodies of the invention are also provided. An antibody, or portion of an antibody, of the present invention detects two different but structurally related antigens (eg, IL-1α and IL-1β) and (eg, IL-1α and / or IL-1β activity is Useful in inhibiting the activity of the antigen) in human patients suffering from harmful diseases. |