http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100912472-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6837 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2007-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100912472-B1 |
| titleOfInvention | SNPs for diagnosis of schizophrenia, supersatellites, microarrays and kits containing them |
| abstract | The present invention relates to a biomarker using SNPs and supersatellites which can detect Korean schizophrenic patients by a genetic method. The present invention relates to genomic DNA from blood of a normal and neuropsychiatric schizophrenic patient. ), The TPI1 (TriosePhosphate Isomerase 1) gene and CKB (Creatine Kinase, Brain-specific) gene, which were extracted from mice lacking the interferon gamma gene and interferon gamma gene reported in the literature as schizophrenic models. The purpose of this study is to use three significant SNPs and hypersatellites as markers for schizophrenia through genotyping (SNP allele frequency and supersatellite polymorphism analysis of CA sequences) from the SNP position of.n n n The present invention provides a polynucleotide of SEQ ID NO: 1, which is a complementary sequence of rs2430561, which forms part of the interferon gamma gene, an rs2071064 polynucleotide of SEQ ID NO: 2, which forms a part of the TPI1 gene, and a sequence of SEQ ID NO: 3, which forms part of the CKB gene. For polynucleotides consisting of rs2765042 polynucleotides, selected from polynucleotides comprising each SNP position (61 th for SEQ ID NO: 2 and 301 th for the remaining SEQ ID NO) and consisting of 20 or more consecutive bases Provided is a SNP for diagnosing schizophrenia comprising one or more polynucleotides or complementary polynucleotides thereof. In addition, the present invention is a polynucleotide of SEQ ID NO: 1, which is a complementary sequence of rs2430561 constituting a part of the interferon gamma gene, comprising a supersatellite polymorphism in which the CA base sequence is repeated from the 302th, and is composed of 40 or more consecutive bases. Provided is a schizophrenia diagnosing polynucleotide comprising a polynucleotide or a complementary polynucleotide thereof.n n n Microarrays and kits comprising the SNPs or supersatellites of the present invention can effectively diagnose the presence or risk of schizophrenia.n n n n Schizophrenia, Interferongamma Gene, TPI1 Gene, CKB Gene, Single Base Polymorphism, SNP, Supersatellite, Microsatellite |
| priorityDate | 2007-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 155.