| abstract |
Disclosed are methods of preventing or treating sepsis, sepsis-related conditions or inflammatory diseases in a mammal. In one embodiment, binding to the complex, comprising administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that specifically binds to a tissue factor (TF) to form a complex Factor X or factor IX is inhibited and the administration is sufficient to prevent or treat sepsis in a mammal. The present invention has a wide range of useful applications including the treatment of sepsis, sepsis related diseases, and inflammatory diseases such as arthritis. |