| abstract |
The present invention relates to compounds of formula (I), which are useful as double inhibitors of angiotensin converting enzymes and neutral endopeptidase and which are inhibitors of endothelin converting enzymes.n n n <Formula I>n n n n n n n n Wherein R, R 1 , COOR 2 , R 3 -R 7 , alk, and X have the meanings defined above. In a preferred embodiment, R and R 5 represent hydrogen; R 1 represents benzyl; R 3 represents hydrogen, acetyl or methoxyacetyl and R 4 represents isopropyl or tert-butyl; R 6 and R 7 represent methyl; X represents -O-; alk represents methylene; COOR 2 represents carboxyl or ethoxycarbonyl. |