| abstract |
Mutant cholera holotoxins comprising a cholera toxin subunit (A) having a single amino acid substitution at amino acid position (16 or 72) or a double amino acid substitution at amino acid positions (16 and 68) or (68 and 72) are wild type Has reduced toxicity compared to cholera holotoxin. Mutant cholera holotoxin is an adjuvant in an immunogenic composition for enhancing an immune response in a vertebrate host against an antigen selected from pathogenic bacteria, viruses, fungi, or parasites, cancer cells, tumor cells, allergens, or autologous molecules. useful.n n n Amino acid substitutions, cholera holotoxin, adjuvant, immune response |