| abstract |
The present invention discloses human monoclonal antibodies that specifically bind to Fc alpha receptors (CD89), including monoclonal antibodies that specifically respond to Fc receptors on IgA of human effector cells. Binding agents (eg, antibodies) are useful for targeting human effector cells (eg, macrophages) against target cells (eg, cancer cells, infectious agents, etc.). For this purpose, bifunctional antibodies or heterologous antibodies can be constructed that have binding regions derived from anti-Fc-alpha receptor antibodies and binding regions of target-specific antibodies. Targeted effector cells can specifically lyse target cells.n n n Human monoclonal antibodies, CD89, effector cells, hybridomas. |