| abstract |
The present invention discloses a solid oral sustained release oral formulation of hydrocodone. This formulation comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof and a sufficient amount of sustained release material suitable for enabling administration twice daily to human patients has a C 12 / C max ratio. 0.55 to 0.85 and provide therapeutic effect for at least 12 hours.n n n n Hydrocodone, sustained release formulation, Cmax, dissolution rate |