| abstract |
The present invention provides a method of inducing cytotoxic T cells with antigen-specific cytotoxic activity, a method of maintaining these cells, a method of continuing culturing these cells, and a method of expanding the cells, (A) CD44. A substance having binding activity, (B) A substance capable of controlling a signal generated by binding of CD44 ligand to CD44, (C) A substance capable of inhibiting growth factor binding to growth factor receptor, (D) A growth factor Culturing cytotoxic T cells in the presence of at least one substance selected from the group consisting of a substance capable of controlling a signal generated by binding to a growth factor receptor of (E) fibronectin, a fragment thereof, or a mixture thereof. Way.n n n n Antigen-Specific, Cytotoxic T Cells |