| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8129548f7ec81010b5ca721964babd2a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-033 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4703
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate |
2008-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b1311097fc303fa226af136d6a3dc74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc09cbc3c0c2c87a327b99b96cf1a41e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbc8b20749a5f5c5e4e3f9ccf0fcd2c6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79d2f144963a086404408ac61845745c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4475f60e3662beafbc25feeabe06512 |
| publicationDate |
2009-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-100887266-B1 |
| titleOfInvention |
Cell Permeable ｐ１８ Recombinant Protein, Polynucleotide Encoding It, and Anticancer Composition Containing It as an Active Ingredient |
| abstract |
The present invention is a macromolecule transduction domain (MTD) fused to a tumor suppressor p18, the cell-permeable p18 recombinant protein, the polynucleotide encoding the cell-permeable p18 recombinant protein, the expression of the cell-permeable p18 recombinant protein The present invention relates to a pharmaceutical composition for anticancer drugs for treating p18 deficiency or loss of function containing the vector and the cell permeable p18 recombinant protein as an active ingredient. The cell-permeable p18 recombinant protein of the present invention delivers p18, a fold-lost-deficient tumor suppressor, into cells, and activates ATM and p53 to induce cell cycle inhibition and apoptosis by DNA damage or tumor formation signals. Since it effectively reactivates the related signaling mechanism, a composition containing it as an active ingredient can be usefully used as an anticancer agent. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9617344-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010064838-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010064838-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010104357-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8859507-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8470971-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9573985-B2 |
| priorityDate |
2007-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |