| abstract |
An object of the present invention is to provide a substance for inhibiting TNF-α production, which is useful as a therapeutic agent for autoimmune diseases such as chronic arthrosis. According to the present invention, a novel compound having a structure represented by the formula (1) or a salt thereof has excellent TNF-α production inhibitory activity.n n n Formula 1n n n n n n n n Wherein A is-(NR 4 )-,-(CR 5 R 6 )-or -O-, B is an alkylene or alkenylene group, R 1 , R 2 , R 4 , R 5 and R 6 are A hydrogen atom, an alkyl group, an alkenyl group, an adamantylalkyl group, etc., R < 3> represents an aryl group or an unsaturated heterocycle, and X represents an oxygen atom or a sulfur atom, respectively. |