| abstract |
The present invention provides an isolated protein designated SdrF, SdrG, or SdrH and its corresponding amino acid and nucleic acid sequences to prevent and treat infections caused by coagulase-negative staphylococci, such as Staphylococcus epidermidis. To use. SdrF, SdrG, or SdrH proteins are proteins associated with cell walls that specifically bind to host proteins, each with a highly conserved motif of the common sequence of TYTFTDYVD. Proteins, antigen portions thereof, and anti-SdrF, SdrG, or SdrH antibodies are also useful for the identification and diagnosis of coagulation-negative staphylococcal infections. In particular, the protein may be used as a vaccine component or an antibody thereof, and may be administered to a wound or coated on a biomaterial to act as a blocking agent that prevents or prevents coagulation-negative staphylococcus from binding to the wound or the biomaterial. It is preferable because it can.n n n Coagulation enzyme-negative, staphylococci, Sdr protein, cell wall adhesion, vaccine, organ transplantation. Fibrinogen binding protein |