abstract |
The present invention relates to novel compositions and methods for treating diseases caused by cell proliferation, specifically for treating cancer in mammals and more specifically in humans. The therapeutic composition of the present invention comprises a SN-38 (7-ethyl-10-hydroxy camptothecin) lipid complex, which may comprise various neutral or charged lipids, and preferably cardiolipin. The composition can effectively bind SN-38 into the complex and dissolve relatively high concentrations of SN-38. |