http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100865602-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B50-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4726 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 2001-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100865602-B1 |
| titleOfInvention | Combinatorial library of proteins with C-type lectin-like domains of scaffold structure |
| abstract | The present invention provides a CTLD (C-type lectin-like domain: C - t ype L ectin-Like D in which an internal polypeptide loop region lining a ligand binding site in DTLD is replaced by an ensemble of fully or partially randomized polypeptide fragments. omains) and a new class of protein libraries. Tetranectin CTLD is selected as a framework for a preferred embodiment of the invention; Multipurpose phagemid vectors useful for the generation and manipulation of human and murine tetranectin CTLD libraries are disclosed as part of the present invention. Tetranectin CTLDs in monomeric as well as trimer form are effectively displayed as gene III fusions in fully functional form by recombinant fd phage display vectors. CTLD derivatives having an affinity for the novel ligands are obtained from a library of vectors displaying CTLDs in which loop regions are randomized using amplification of each enriched subassembly after one or several enrichments by screening or selection. Can be easily separated. The efficiency with which protein products containing CTLDs with novel binding properties can be produced by bacterial expression in the form of monomers, trimers, or multimers, for example by in vitro refolding, can be produced, produced, compared to recombinant antibody derivatives, It offers important advantages in terms of simplicity, cost, and efficiency when applied for diagnosis or treatment. |
| priorityDate | 2000-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 715.