| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-24263
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-205
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16263
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-18663
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2720-00063
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5252
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5254
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16222
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16151
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16163 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-44 |
| filingDate |
2001-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2008-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2008-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-100862758-B1 |
| titleOfInvention |
DNA transfection system for infectious influenza virus production |
| abstract |
The present invention is based on the development of a dual promoter system (preferably RNA pol I-pol II system) for the effective intracellular synthesis of viral RNA. The resulting minimal plasmid based system can be used to synthesize any RNA virus, preferably a virus with a negative single stranded RNA genome. The viral product of the system is produced when the plasmid of the system is introduced into a suitable host cell. One application of this system is to produce a reclassified influenza virus that is sensitized for use as an antigen in a vaccine. Reclassification viruses generated by cotransfection of the plasmid may include genes encoding the surface glycoproteins hemagglutinin and neuraminidase of the influenza virus that infect the current population and the internal genes of the mutated influenza virus. have. An advantageous feature of the present invention is its versatility; The system can quickly and easily synthesize a weakened form of any RNA virus. Attenuated or inactivated RNA produced by the present invention can be administered to a patient in need of vaccination by one of several routes including intranasal or intramuscular. |
| priorityDate |
2000-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |