| abstract |
Novel pyrimidine and pyridine based compounds, compositions and methods that inhibit the activity of glycogen synthase kinase 3 (GSK3) in vitro and methods of treating GSK3 mediated diseases in vivo. The methods, compounds and compositions of the present invention, alone or in combination with other pharmaceutically active agents, can cause diabetes, Alzheimer's disease and other degenerative neurological diseases, obesity, atherosclerosis cardiovascular disease, idiopathic hypertension, polycystic ovary syndrome, syndrome X, ischemia , In particular cerebral ischemia, traumatic brain injury, bipolar disorder, immunodeficiency and cancer, and can be used to treat diseases mediated by GSK3 activity.n n n Glycogen synthase kinase 3, GSK3, pyrimidine, pyridine, diabetes, Alzheimer's disease |