| abstract |
Fluorine substituted cycloalkanoindole derivatives of formula (I) and pharmaceutically acceptable salts thereof are antagonists of prostaglandins, which are useful for the treatment of prostaglandin mediated diseases:n n n Formula In n n n n n n n In the above formula,n n n n is 0 or 1;n n n m is 1, 2 or 3;n n n R 1 is H, C 1 -C 3 alkyl, halogenated C 1 -C 3 alkyl or cyclopropyl;n n n R 2 is 4-chlorophenyl or 2,4,6-trichlorophenyl. n n n Prostaglandin D2 receptor antagonists, cycloalkanoindoles, antihistamines, leukotriene antagonists, leukotriene biosynthesis inhibitors, prostaglandin D2-mediated diseases |