| abstract |
The present invention relates to an anti-thrombotic pharmaceutical composition comprising cilostazol and aspirin and a method for preparing the same, and in particular, an anti-thrombotic pharmaceutical composition having an effective dosage form that can minimize side effects and increase the efficacy even at a low dosage, and a method for preparing the same. It is about. In the present invention, (a) 1 part by weight of aspirin enteric polymer coated with 0.01 to 0.4 parts by weight of enteric polymers; (b) 1.5 to 2.5 parts by weight of cilostazol, and then coated with 0.01 to 0.4 parts by weight of a water-soluble polymer, a cilostazol water-soluble polymer coating pellet is provided. The composition of the present invention is to separate the coating cilostazol and aspirin in one formulation so that the cilostazole in the composition is released in the stomach to act on the small intestinal mucosa and aspirin is released in the intestine to act on the intestine, It prevents the action and maximizes the expression of the drug. In addition, the composition of the present invention improves the stability of each component, minimizes side effects, and the drug efficacy is increased even at a lower dosage than when each drug is administered. |