http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100842351-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_259045c6eba6e2c5d338b84e0a88b571 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 |
| filingDate | 2007-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf0a2d5a728d8294cd3e04d5fc493a9a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8483ceb8a090f090056f0e4964f8f02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f68e2b4ff46ccbb383f5e8d085cc64b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_432d15fb03d6a3ef38a33c01e1a9c2bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3be173e25b26f456b5aeb914bc6f4ec8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9b7e8e845e4810c51f7d9786fc0aab3 |
| publicationDate | 2008-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100842351-B1 |
| titleOfInvention | Cancer preventive and therapeutic pharmaceutical composition containing an indole derivative as an active ingredient |
| abstract | The present invention relates to a pharmaceutical composition for preventing and treating cancer containing an indole derivative as an active ingredient, wherein the indole derivative of the present invention does not exhibit anticancer activity by non-selective cytotoxicity, but is important for growth and metastasis of cancer cells. It inhibits the activity of HIF-1, a transcription factor that plays a role, and shows anticancer activity. Therefore, the indole derivatives or pharmaceutically acceptable salts thereof according to the present invention can be used as a therapeutic agent for various cancer diseases such as liver cancer, stomach cancer, breast cancer by inhibiting HIF-1 activity. In addition, the indole derivative according to the present invention or a pharmaceutically acceptable salt thereof may be used as an active ingredient of a therapeutic agent for diabetic retinopathy or arthritis which is exacerbated by an increase in expression of VEGF by HIF-1 in a hypoxic state.n n n n Formula 1n n n n n n n n n (Wherein R is as defined in the specification). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101586037-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10301598-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20130133638-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9587225-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013180350-A1 |
| priorityDate | 2007-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.