| abstract |
The present invention relates to a transglutaminase inhibitor, and specifically, to provide a peptide that inhibits transglutaminase, the peptide or the composition for transglutamin inhibition comprising the same and a transglutaminase using the same It provides a method of inhibiting, preferably a method of treating a variety of inflammatory and cancer diseases by inhibiting transglutaminase. The present invention also provides a method for preparing a variant of the peptide.n n n Peptides of the present invention or pharmaceutical compositions comprising the same can effectively prevent and treat diseases induced by abnormal activity of transglutaminase, specifically inflammatory diseases and cancer.n n n n I-kappaBalpha (I-κBα), transglutaminase, Nuclear factor-kappaB (NF-κB), inflammation, cancer |