http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100832347-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a251ae79dd7a008d95010b238c6aa1f8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-685 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-66 |
| filingDate | 2006-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e71d7e51bf348f12b814177c9d55a00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d1d4a48c649159e7298aa0be7629d50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f33c043e0aab7e41ca4d39264853328 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5874fa46107fcb74b2e182279d883008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5a1572de12eefa1cd3abf6da39cada4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45ff0143d8a054860055ee3aeffda6e4 |
| publicationDate | 2008-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100832347-B1 |
| titleOfInvention | Composition for inducing differentiation of mesenchymal stem cells containing sphingosylphosphorylcholine into myofibroblasts |
| abstract | The present invention relates to a composition for inducing differentiation of mesenchymal stem cells into myofibroblasts containing sphingosylphosphorylcholine as an active ingredient.n n n According to the present invention, sphingosylphosphorylcholine (SPC) promotes secretion of transforming growth factor-β1 (TGF-β1) in mesenchymal stem cells, thereby promoting α-smooth muscle actin (α), which is a specific gene of myofibroblast. -SMA), calponin, SM22α and the like to increase the expression of the extracellular matrix (extracellular matrix protein), fibronectin (fibronectin) and the like. Therefore, SPC can be used as a drug to increase the efficacy of cell therapy for the treatment of skin wounds using mesenchymal stem cells, and the method of inducing and measuring the differentiation of mesenchymal stem cells into myofibroblasts by SPC can promote wound recovery or scarring. It can be used to search for inhibitors of production. |
| priorityDate | 2006-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.