| abstract |
The present invention describes a simplified and efficient method for preparing recombinant adenoviruses using liposome-mediated co-transfection and direct observation of cytopathic effect (CPE) in transfected cells. Also described are compositions and methods comprising the novel p53 adenovirus constructs, including methods for restoring p53 action and tumor suppression in cells and animals with abnormal p53.n n n n p53, adenovirus, chemotherapy, constitutive promoter, recombinant adenovirus |