| abstract |
The present invention relates to a drug-controlled metformin-glymepiride combination formulation, and more particularly, to a sustained release layer by specifically selecting and designing a release controlling substance so that the release of metformin having a high water solubility and a high unit dosage is continuously performed for 24 hours. And the immediate release layer so that the content of glymepiride with low water solubility and low unit dose is maintained uniformly, and the rapid release layer is configured so that the excipient constituting the sustained release layer cannot affect the rapid release of glymepiride. By implementing a multi-layered formulation that completely blocks the release layer of the immediate release layer, the phase separation between metformin and glymepiride is minimized, minimizing the interaction of each drug and the effects of each drug are complementary. Drugs for oral administration effective for type diabetes Air-release metformin relates to a combined preparation glimepiride. |