| abstract |
The present invention relates to a high bioavailability sustained-release preparation composition containing exendin as an active ingredient, exendin-containing sustained-release microspheres and a method for producing the same. More specifically, the present invention includes exendin as an active ingredient, a biodegradable polymer having a specific viscosity, and a coating material, so that the bioavailability of the sustained release can be sustained at an effective concentration for a certain period of time without excessive initial release of the active ingredient. Sex agent compositions; A core comprising exendin as an active ingredient and a biodegradable polymer encapsulating the same; And sustained-release microspheres comprising a coating layer coating the core; And mixing exendin, a biodegradable polymer, and a solvent, removing the solvent from the mixture to produce cured microspheres, and forming a coating material coating layer on the cured microsphere surface. It relates to a method for producing.n n n n Exendin, Biodegradable Polymer, Sustained Release Microspheres, Initial Release, Bioavailability |