| abstract |
The present invention relates to an isoindole-imide compound of Formula 1, a pharmaceutically acceptable salt thereof, a hydrate, a solvate, a clathrate compound, an enantiomer, a diastereomer, a racemate and a mixture of these stereoisomers; Pharmaceutical compositions comprising such isoindole-imide compounds and methods for reducing the levels of cytokines and precursors thereof in mammals. More specifically, the present invention relates to isoindole-imide compounds which are potent inhibitors for the production of TNF-α in mammals. Isoindole-imide described herein may be used for diseases or diseases of mammals, such as cancers such as solid tumors and hematologic tumors; Heart diseases such as congestive heart failure; osteoporosis; And for the treatment or prevention of hereditary, inflammatory, allergic and autoimmune diseases.n n n Formula 1n n n n n n n n In the above formula, the definition of the substituent is as defined in the specification. |