| abstract |
The present invention relates to thienopyridine derivatives useful as anti-inflammatory drugs, especially pharmaceuticals for arthritis; Methods of making them and pharmaceutical compositions containing them are provided. Thienopyridine derivatives are represented by Formula I:n n n [Formula I]n n n n n n n n [Wherein G is a halogen atom, a hydroxyl group, an optionally substituted amino group, or the like; alk is an optionally substituted lower alkylene group; X is O, S,-(CH 2 ) q -and the like; R is an optionally substituted amino group or the like; Ring B is an optionally substituted Y-containing 5- to 8-membered ring wherein the ring constituent atoms do not contain a nitrogen atom; Y is O, S, the following groups:n n n n n n n n Wherein Ra, Rb and Rc are the same or different and each is H, a halogen atom, an optionally substituted hydrocarbon group, or the like; Ring A may be substituted]. |