| abstract |
In the present invention, IL-12, GM-CSF, IL-1, TNF-α, TNF-β, IL-2, IL-4, IL-5, IL-10, IL-15, operably linked with regulatory factors Improved vaccines comprising nucleotide sequences encoding IL-18 and / or BL-1 are disclosed. Improved vaccines include DNA vaccines, recombinant vaccines carrying foreign antigens, and attenuated live vaccines. Methods of immunization of individuals are also disclosed. Consisting of IL-12, GM-CSF, IL-1, TNF-α, TNF-β, IL-2, IL-4, IL-5, IL-10, IL-15, IL-18, and BL-1 Pharmaceutical compositions comprising nucleic acid molecules encoding one or more immunomodulatory proteins selected from the group are disclosed. Immunregulatory proteins, BL1, and nucleic acid molecules encoding BL1 are also disclosed. Methods of making and using BL1 are also disclosed.n n n n Antigen, vaccine, immunomodulatory protein, BL1, regulatory factor, target protein, IL-12 |