| abstract |
The present invention relates to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions including increased vascular resistance and heart failure. Pharmaceutical compositions comprising the tricyclic benzodiazepines of the present invention and hypertension, congestive heart failure, heart failure, coronary angioplasty, heart ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, seizures, thrombosis, and water retention and Also disclosed are methods of treating the same symptoms. |