| abstract |
The present invention relates to a multi-step synthesis method for preparing a 4,5-diamino sikimic acid derivative of the general formula (1a) starting from an isophthalic acid derivative of the general formula (2):n n n n n n n n n n n n n n n n n In the above formulas,n n n R 1 is a substituted or unsubstituted alkyl group;n n n R 2 is an alkyl group;n n n R 3 and R 4 are independently of each other a substituent of H or an amino group, provided that R 3 and R 4 are not both H;n n n R 5 is H or lower alkyl.n n n The 4,5-diamino shikimic acid derivative is a potent inhibitor of viral neuraminidase. |