http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100753674-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S424-825 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-552 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0241 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-12 |
| filingDate | 2006-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100753674-B1 |
| titleOfInvention | Method for producing live vaccine using gel-added diluent adsorbed gel or immune enhancing substance |
| abstract | To improve the immune efficacy of lyophilized attenuated live vaccines, a gel or adsorbed gel was adsorbed to the diluent of the live vaccine and tested as a test model for live don vaccine, swine atrophic non-inflammatory vaccine and open wave attenuated virus vaccine. The effects on immunity were tested and the following results were obtained.n n n 1. Effect on the immunogenicity of live single vaccinen n n Various immunopotentiators such as antibodies were adsorbed to the gel or gel, and added to the diluent. The monoclonal vaccine was suspended with this diluent to inoculate mice. After 2 weeks of inoculation, the antibody titer was examined. The antibody titer of the vaccine in which the floating mouse was inoculated with a diluent containing 2% of the gel was 1: 256 higher than that of 1: 128. However, the antibody value of the vaccine in which the added gel concentration was high or the vaccine inoculated by adsorbing an adjuvant or the like on the gel and suspended in the dilution solution was lower than that of the vaccine using the diluent without the gel.n n n As a result of investigating the defense effect of challenged vaccination of the floating single-dose live bacterial vaccine by diluting solution, the diluent solution containing 2% gel, antibody (1:20) adsorption gel, Glucan adsorption gel, and gel containing porcine complement The protective effect of the floating vaccine was 100% regardless of the antibody value, which was superior to the protective effect of 83.3% of the vaccine, which was suspended in a diluent. However, high concentration of gel (5-10%) and high titer antibody (1: 320) and the protective effect of the vaccination group suspended in diluent with the addition of gel adsorbed as a developmental adjuvant was similar to or lower than that of the vaccine suspended with diluent.n n n 2. Swine atrophic rhinitis live vaccinen n n 2, 5% of the gel was added to the diluted solution, and the diluted vaccine was used to inoculate the virulent atrophic viable vaccine and inoculated into the mouse, and the antibody titer was examined. The antibody value of the vaccine suspended in the diluent containing 1% gel was 1: 512, but the antibody value of the vaccine suspended in the diluent containing 5% gel adsorbed was 1:32. The antibody was lower than. The protective effect after inoculation of mice with 10-fold dilutions of vaccine and challenge vaccination was 62.5% for the 2% gel-free diluent vaccine and the gel-free diluent vaccine. Lower than this.n n n 3. Canpabovirus Attenuated Vaccinen n n 2, 5% of the gel was added to the diluted solution, and the diluent was suspended in the live canpavovirus vaccine and inoculated twice in the guinea pigs according to the national standard for veterinary drug testing. Among them, no antibody was detected in the guinea pigs inoculated with a diluent without adding the existing gel, but the serum of the gel-added group detected 1: 8 antibody early, and the antibody titer after 10 days of the second inoculation was also detected. The antibody titer of the non-vaccinated group was 1:24, but the antibody titers of the group inoculated by dilution with 2% and 5% gels were markedly high: 1: 106.7 and 1:96 (64, 128).n n n 4. Immunogenicity of Pig-Only Proliferative Vaccines against Pigletsn n n A 2% gel or gel adsorbed with Glucan, an adjuvant, was added to the diluent and suspended with a monoclonal vaccine. The vaccine was then subcutaneously inoculated into 50-day-old weaned pigs with negative monoclonal antibody. The average antibody titers of vaccinated piglets suspended with diluent added 2% gel or Glucan adsorbed gel were higher than 1:32, respectively.n n n In conclusion, it could be confirmed that the immunogenicity of the vaccine can be improved by adsorbing the adjuvant to the gel or gel in the lyophilized attenuated vaccine diluent.n n n Attenuated vaccine, diluent, aluminum gel, immune booster |
| priorityDate | 2006-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.