| abstract |
The present invention relates to a method of inhibiting p38-α kinase using a compound of Formula 1 and a pharmaceutically acceptable salt thereof, or a pharmaceutical component thereof:n n n Formula 1n n n n n n n n Wheren n n Represents a single or double bond;n n n One Z 2 is CA or CR 8 A and the other is CR 1 , CR 1 2 , NR 6 or N, wherein R 1 , R 6 and R 8 are each independently hydrogen or a non-interfering substituent;n n n A is -W i -COX j Y, wherein Y is COR 2 or isotope thereof and R 2 is hydrogen or non-interfering substituent, W and X are each 2-6 스페이서 spacer, i and j are each independently 0 Or 1);n n n Z 3 is NR 7 or O;n n n R 3 are each independently a non-interfering substituent;n n n n is 0 to 3;n n n L 1 and L 2 are each a linker;n n n Each R 4 is independently a non-interfering substituent;n n n m is 0-4;n n n Z 1 is CR 5 or N, wherein R 5 is hydrogen or a non-interfering substituent;n n n l and k are each an integer of 0 to 2 and the sum of l and k is 0 to 3;n n n Ar is an aryl group substituted with 0 to 5 non-interfering substituents, wherein the 2 non-interfering substituents may form a fused ring;n n n The distance between the atom of Ar linked to L 2 and the center of the alpha ring is 4.5 to 24 kV.n n n p38 kinase inhibitors, indole derivatives, pro-inflammatory reactions, piperazine, piperidine |