| abstract |
The present invention is directed to pyrimidine derivatives of formula (I), pharmaceutically acceptable salts or in vivo degradable esters thereof, methods for their preparation, pharmaceutical compositions comprising them, and their use in the treatment of diseases or medical conditions mediated by cytokines. It is about.n n n Formula In n n n n n n n Wherein m is 0-3, each R 1 is a group such as hydroxy, halogeno, trifluoromethyl and cyano, R 3 is hydrogen, halogeno or C 1 -C 6 alkyl, n Is 0 to 2 , each R 2 group is a group such as hydroxy, halogeno, trifluoromethyl and cyano, p is 0 to 4 and Q 1 is aryl or heteroaryl. |